Hydroxypropyl Methyl Cellulose (HPMC) K4M

Hydroxypropyl Methyl Cellulose K4M is a high-viscosity cellulose ether derived from natural cellulose, and one of the most established polymers in modified-release technology. On contact with aqueous fluids it hydrates quickly and forms a coherent gel layer that controls the diffusion of drugs from tablet matrices, enabling predictable extended-release profiles over many hours. Its proven record across decades of controlled-release products makes it the reference grade for both new developments and line extensions. The polymer is non-ionic, plant-derived and highly compatible with actives and fillers of all kinds. Compliant with USP requirements and produced with tight viscosity control, it provides a dependable foundation for sustained-release tablets, thickening and stabilizing applications worldwide. It is packed in 25 kg fiber drums. Its gel strength also stabilizes suspensions in liquid medicines without settling. Its release-controlling behavior is among the most reproducible in the industry. In practice it is the first choice for extending release in generic matrix tablets because its behavior is documented across countless products and pharmacopeias. It also thickens and stabilizes oral liquids where proven performance matters. Batch records and test reports are available for every delivery, supporting buyer qualification, regulatory filing and long-term supply relationships. How K4M works: with its high viscosity and rapid hydration, K4M has been the release-controlling polymer behind a generation of extended-release products. On contact with gastric fluid it forms a coherent gel barrier that retards diffusion, releasing the drug steadily over hours. Its behavior is documented across countless products and pharmacopeias, which makes formulation work and regulatory filing faster and safer. Practical guidance: build hydrophilic matrices for extended-release tablets; control release of both low- and high-solubility drugs; thicken and stabilize oral liquids; and use its film-forming properties in topical and capsule applications. Quality assurance: produced under USP requirements with viscosity, methoxy and hydroxypropoxy content and microbial limits tested per batch, documented for regulatory files. Packed in 25 kg fiber drums. For development teams, K4M is the proven choice that de-risks controlled-release projects from day one. Specification highlights: it is packed in 25kg/drum with a minimum order quantity of 1000kg. Certificates of analysis accompany every shipment, and sample supply, specification customization and flexible payment terms are available for qualified buyers, supported by the standardized seven-step service process from inquiry to after-sales support. Documented quality from batch to batch: every production lot is verified against the full specification - identity, purity, heavy metals and microbiology - before release, and the resulting certificates and batch records travel with each shipment to support qualification and audit. Raw materials are sourced to defined standards, storage follows the conditions stated in the specification, and the product ships in its original, intact packaging. Shelf life and storage requirements are clearly documented, so purchasing, warehouse and quality teams all work from the same reference. This repeatable quality system is what makes the grade dependable for multi-year supply agreements.

Applications

It is the classic hydrophilic matrix former in extended-release tablets, controlling release of drugs from a few hours to a full day. Liquid formulations use it as a thickener and suspension stabilizer, and topical products benefit from its film-forming and mucoadhesive properties. Food and nutraceutical applications use it to thicken and stabilize products, and it appears in plant-based capsule and coating systems.

Advantages

K4M is the industry's best-documented controlled-release polymer, which de-risks formulation work and regulatory filings - teams know exactly how it behaves in matrices. Its rapid hydration forms the gel barrier early, preventing dose dumping and smoothing release curves. USP compliance, tight viscosity control and dependable supply make it the safe, proven choice for extended-release development.

Hydroxypropyl Methylcellulose K4M

Comply with USP

Cas No. 9004-65-3 H.S. Code 39129000

Main Purpose: Tablet film coating, binders,main material of plant capsules.

Package: 25.0kg/fiber drum

Packing Size: D37cm*H53cm

G.W. 27.5kg

Shelf Life: 2 years

Storage Condition: Preserve in well-closed containers.

Q1 : Do you provide samples? is it free or extra?

Yes, we could offer the sample for free charge but do not pay the cost of freight.

Q2 : Do you accept customization?

We can produce according to your indicators.For specific details, please consult

Q3 : How long is your delivery time?

Generally it is 5-10 days if the goods are in stock. or it is 15-20 days if the goods are not in stock.

Q4 : What is your payment terms?

T/T, L/C, Credit Card, PayPal, Cash.

Accepted Payment Currency:USD,EUR,JPY,CAD,AUD,HKD,GBP,CNY,CHF;

Q5 : How do you ship the products?

By Sea ,By Air ,By courier, Fedex, UPS Etc. It is up to you.

Q6 : What’s the MOQ?

Different products result in different MOQ

For specific details, please consult

1) Inquiry --- Share your initial requirements with us; we will establish a communication channel and learn about your needs and background.

2) Requirement Alignment --- We discuss technical parameters, application scenarios and regulatory requirements in depth to define the details and delivery standards.

3) Product Confirmation & Quotation --- We provide compliant product options and a detailed quotation covering specifications, pricing and minimum order quantity.

4) Order Processing & Payment Plan --- Contract terms are confirmed and flexible payment arrangements are made, keeping every transaction safe and compliant.

5) Shipping Plan --- We select the optimal shipping route and coordinate customs clearance and insurance to ensure your cargo is dispatched safely and on time.

6) Inspection & Tracking --- We provide quality inspection reports and full logistics tracking, keeping product quality controlled and the shipment fully transparent.

7) After-sales Service --- Technical support, prompt issue response and continuous improvement suggestions build a long-term partnership and ensure your satisfaction.