Hydroxypropyl Methyl Cellulose (HPMC K100M)

Hydroxypropyl Methyl Cellulose K100M is an ultra-high-viscosity cellulose ether derived from natural cellulose. In water it hydrates into very viscous, clear solutions and forms strong gels upon heating, which makes it the reference polymer for hydrophilic matrix systems. In controlled-release tablets, the grade hydrates rapidly on contact with gastric fluid and forms a robust gel barrier that retards drug release over many hours, enabling once-daily dosing. Its non-ionic, plant-derived nature gives it excellent compatibility with actives of all charge types and broad regulatory acceptance. Compliant with USP requirements and produced with tight viscosity control, it is a dependable, high-performance polymer for controlled-release, thickening and protective formulations worldwide. The grade is also valued for its strong mucoadhesion in topical systems. It is packed in 25 kg fiber drums. The grade also builds high clarity in gels and lubricating ophthalmic solutions. In practice matrix tablets containing K100M hydrate to a firm gel within minutes of ingestion, releasing the drug steadily over many hours regardless of stirring conditions in the stomach. It also thickens artificial tears and topical gels. Batch records and test reports are available for every delivery, supporting buyer qualification, regulatory filing and long-term supply relationships. How K100M works: with an ultra-high nominal viscosity, K100M hydrates on contact with aqueous fluids into a firm, coherent gel layer that controls drug diffusion out of matrix tablets. The gel forms quickly - before the tablet can disintegrate - preventing dose dumping and smoothing the release curve over many hours, which enables once-daily dosing. Practical guidance: compress matrix tablets with the polymer as the release-controlling agent; design matrices for highly soluble drugs that need long retardation; use its mucoadhesion in ophthalmic and topical protective products; and thicken gels and suspensions where high viscosity is required. Quality assurance: produced under USP requirements with viscosity, methoxy and hydroxypropoxy content and microbial limits tested per batch, documented for regulatory files. Packed in 25 kg fiber drums. For controlled-release formulators, K100M is the ultra-high-viscosity standard for long-duration delivery. Specification highlights: it is packed in 25kg/drum with a minimum order quantity of 1000kg. Certificates of analysis accompany every shipment, and sample supply, specification customization and flexible payment terms are available for qualified buyers, supported by the standardized seven-step service process from inquiry to after-sales support. Quality system overview: production follows the food-grade or pharmacopeia standards listed in the specification, with defined raw-material sourcing, in-process checks and final release testing on every batch. Purity, heavy-metal and microbiological results are documented, and the complete dossier - specification, certificate of analysis and batch records - is available to support buyer audits and regulatory dossiers. Original packaging is maintained through storage and shipping to protect the product, and shelf life is stated on the specification. Buyers qualify once and rely on the same documented quality for every subsequent order.

Applications

It is used as the matrix former in controlled-release tablets, particularly for once-daily formulations of high-solubility drugs. In topical and ophthalmic products it acts as a strong viscosity builder and lubricating, protective agent. Food and personal care use it to thicken gels, sauces and creams, and it stabilizes suspensions in liquid medicines.

Advantages

The ultra-high viscosity of K100M creates the firm gel barrier needed for long, predictable release profiles, letting formulators design once-daily products with fewer polymers and simpler matrices. Its thermal gelation and excellent mucoadhesion also suit topical and ophthalmic protective formulations. USP compliance and tight batch-to-batch viscosity control protect release consistency, the critical quality attribute of controlled-release products.

Hydroxypropyl Methylcellulose K100M

Comply with USP

Cas No. 9004-65-3 H.S. Code 39129000

Main Purpose: Tablet film coating, binders,main material of plant capsules.

Package: 25.0kg/fiber drum

Packing Size: D37cm*H53cm

G.W. 27.5kg

Shelf Life: 2 years

Storage Condition: Preserve in well-closed containers.

Q1 : Do you provide samples? is it free or extra?

Yes, we could offer the sample for free charge but do not pay the cost of freight.

Q2 : Do you accept customization?

We can produce according to your indicators.For specific details, please consult

Q3 : How long is your delivery time?

Generally it is 5-10 days if the goods are in stock. or it is 15-20 days if the goods are not in stock.

Q4 : What is your payment terms?

T/T, L/C, Credit Card, PayPal, Cash.

Accepted Payment Currency:USD,EUR,JPY,CAD,AUD,HKD,GBP,CNY,CHF;

Q5 : How do you ship the products?

By Sea ,By Air ,By courier, Fedex, UPS Etc. It is up to you.

Q6: What’s the MOQ?

Different products result in different MOQ

For specific details, please consult

1) Inquiry --- Share your initial requirements with us; we will establish a communication channel and learn about your needs and background.

2) Requirement Alignment --- We discuss technical parameters, application scenarios and regulatory requirements in depth to define the details and delivery standards.

3) Product Confirmation & Quotation --- We provide compliant product options and a detailed quotation covering specifications, pricing and minimum order quantity.

4) Order Processing & Payment Plan --- Contract terms are confirmed and flexible payment arrangements are made, keeping every transaction safe and compliant.

5) Shipping Plan --- We select the optimal shipping route and coordinate customs clearance and insurance to ensure your cargo is dispatched safely and on time.

6) Inspection & Tracking --- We provide quality inspection reports and full logistics tracking, keeping product quality controlled and the shipment fully transparent.

7) After-sales Service --- Technical support, prompt issue response and continuous improvement suggestions build a long-term partnership and ensure your satisfaction.